Product Name: AICAR
Alternate Name/Synonyms: 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside; AICA-Riboside; NSC 105823
Description: A cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle. AICAR is able to activate the molecular circuitry of pluripotency in mESC and to induce the expression of several key regulators of pluripotency in somatic cells. AMP-活化蛋白激酶（AMPK）的细胞渗透性激活剂，AMPK是参与细胞和全身能量平衡的代谢传感器。 在体内，AMPK与AICAR的药理活性模拟运动并引发骨骼肌对胰岛素非依赖性葡萄糖的摄取。 AICAR能够激活mESC中多能性的分子回路并诱导体细胞中多种关键多能性调节因子的表达